Publications
Ide AH, DeLuca KF, Wiggan O, Markus S, DeLuca JG. The role of kinetochore dynen in checkpoint silencing is restricted to disassembly of the corona. (2023). MBOC. [link]
Jana A, Sarkar A, Zhang H, Agashe A, Wang J, PaulR, Gov NS, DeLuca JG and Nain AS. Mitotic outcomes and errors in fibrous environments (2023). Proc Natl Acad Sci. [link]
DeLuca KF, Mick JE, DeLuca JG. Production and purification of recombinant monoclonal antibodies from human cells based on a primary sequence (2022). STAR Protocol. [link]
Jacob A. Herman, Romario R. Romain, Pia Hoellerbauer, Hazheen K. Shirnekhi, David C. King, Keith F. DeLuca, Erin Osborne Nishimura, Patrick J. Paddison, and Jennifer G. DeLuca. Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities (2022). PNAS [link]
Deluca KF, Mick JM, Ide AH, Lima WC, Sherman L, Schaller KL, Schaller KL, Anderson SM, Zhao N, Stasevich TJ, Varma D, Nilsson J, DeLuca JG. Generation and diversification of recombinant monoclonal antibodies (2021). Elife [link]
Tekaterina V Tarasovetc, Praveen Kumar Allu, Robert Wimbish, JennierG DeLuca, Ian M Cheeseman, Ben E Black, Ekaterina L Grishchuk (2021). Permitted and restricted steps of human kinetochore assembly in mitotic cell extracts. Mol Bill Cell. [link]
Shirnekhi HK, Herman JA, Paddison PJ, DeLuca JG (2020). BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis. J Biol Chem. [link]
Wimbish RT, DeLuca KF, Mick JE, Himes J, Jimenez- Sanchez Jeyaprakash AA, DeLuca JG. (2020). The Hec1/ Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore-microtubule attachment formation and Ska complex recruitment. Mol Biol Cell. [link]
Broad AJ, DeLuca JG. (2020). The right place at the right time: Aurora B kinase localization to centromeres and kinetochores. Essays Biochem. [link]
Wimbish R, DeLuca JG. (2020). Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface. Front. Cell Dev. Biol. [link]
Broad AJ, DeLuca KF, DeLuca JG. (2020). Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells. J Cell Biol. [link]
Heasley LR, DeLuca JG, Markus SM. (2019). Effectors of the spindle assembly checkpoint are confined within the nucleus of Saccharomyces cerevisiae. Biol Open. [link]
DeLuca JG. (2018). Aurora A Kinase Function at Kinetochores. Cold Spring Harb Symp Quant Biol. [link]
DeLuca KF, Meppelink A, Broad AJ, Mick JE, Peersen OB, Pektas S, Lens SMA, DeLuca JG. (2018). Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics. J Cell Biol. [link]
Ruggeri E, DeLuca KF, Galli C, Lazzari G, DeLuca JG, Stokes JE, Carnevale EM. (2017) Use of Confocal Microscopy to Evaluate Equine Zygote Development After Sperm Injection of Oocytes Matured In Vivo or In Vitro. Microsc Microanal. [link]
Lee R, Pain M, Wang H, Herman JA, Toledo CM, DeLuca JG, Yong RL, Maddison P, Zhu J. (2017) Sensitivity to BUB1B inhibition defines an alternative classification of glioblastoma. Cancer Res. [link]
Shirnekhi HK, Kelley EP, DeLuca JG, Herman JA. (2017) Spindle assembly checkpoint signaling and sister chromatid cohesion are disrupted by HPV E6-mediated transformation. Mol Biol Cell. [link]
Heasley LR, Markus SM, DeLuca JG. (2017) “Wait anaphase” signals are not confined to the mitotic spindle. Mol Biol Cell. [link]
Wiggan O, Schroder B, Drapf D, Bamburg JR, DeLuca JG. (2017). Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module. Sci Rep. [link]
Tatsuya Morisake, Kenneth Lyon, Keith F. DeLuca, Jennifer G. DeLuca, Brian P. English, Zhengjian Zhang, Luke D. Lavis, Jonathan B. Grimm, Sarada Viswanathan, Loren L. Looger, Timothy Lionnet, Timothy J. Stasevich. (2016). Real-time quantification of single RNA translation dynamics in living cells. Science [link]
Jeffrey J. Field, Keith A. Warning, Scott R. Domingue, Alyssa M. Allende Motz, Keith F. DeLuca, Dean H. Levi, Jennifer G. DeLuca, Michael D. Young, Jeff A. Squier, Randy A. Bartels. (2016) Superresolved multiproton microscopy with spatial frequency-modulated imaging. PNAS. [link]
DeLuca KF, Herman JA, DeLuca JG. (2016). Kinetochore-Microtubule Attachment Stability in Cultured Cells. Methods in Mol Biol. [link]
Yusuke Abe, Kosuke Sako, Kentaro Takagaki, Youko Hirayama, Kazuhiko S.K. Uchida, Jacob A.Herman, Jennifer G. DeLuca, Toru Hirota. (2016) HP1-Assisted Aurora B Kinase Activity Prevents Chromosome Segregation Errors. Dev. Cell. [link]
Tauchman EC, Boehm FJ, DeLuca JG. (2015) Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells. Nat Comm. [link]
Zaytsev AV, Mick JE, Maslennikov E, Nikashin B, Jennifer G. DeLuca, Ekaterina L. Grishchuk. (2015). Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity. Mol Biol Cell. [ link ]
Ruggeri E, DeLuca KF, Galli C, Lazzari G, DeLuca JG, Carnevale EM. (2015). Cytoskeletal alterations associated with donor age and culture interval for equine oocytes and potential zygotes that failed to cleave after intracytoplasmic sperm injection. Reprod Fertil Dev. [ link ]
Szerlong HJ, Herman JA, Krause CM, DeLuca JG, Skoultchi A, Winger QA, Prenni JE, Hansen JC. (2015). Proteomic characterization of the nucleolar linker histone h1 interaction network. J Mol Biol. [ link ]
Suzuki A, Badger BL, Wan X, DeLuca JG, Salmon ED. The architecture of CCAN proteins creates a structural integrity to resist spindle forces and achieve proper Intrakinetochore stretch. (2014). Dev Cell. [ link ]
Herman JA, Toledo CM, Olson JM, DeLuca JG, Paddison PJ. (2015). Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer. Clin Cancer Res. [ link ]
Anatoly V. Zaytsev, Lynsie J.R. Sundin, Keith F. DeLuca, Ekaterina L. Grishchuk, Jennifer G. DeLuca. (2014). Accurate Phosphoregulation of kinetochore-microtubule affinity requires unconstrained molecular interactions. J. Cell Biol. [link]
Toledo CM, Herman JA, Olsen JB, Ding Y, Corrin P, Girard EJ, Olson JM, Emili A, DeLuca JG, Paddison PJ. (2014). BuGZ is Required for Bub3 Stability, Bub1 Kinetochore Function and Chromosome Alignment. Developmental Cell. [ link ]
Caldas GV, DeLuca KF, DeLuca JG. (2013). KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity. J Cell Biol. [ link ]
Caldas GV, DeLuca JG (2013). KNL1: bringing order to the kinetochore. Chromosoma. [ link ]
Caldas GV, DeLuca JG. (2013). Mad2 "opens" Cdc20 for BubR1 binding. Mol Cell. [ link ]
Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley........ Cleveland DW. (2013). Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. [ link ]
Kalashnikova AA, Winkler DD, McBryant SJ, Henderson RK, Herman JA, DeLuca JG, Luger K, Prenni JE, Hansen JC. (2013). Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus. Nucleic Acids Res. [ link ]
Ding Y, Hubert CG, Herman J, Corrin P, Toledo CM, Skutt-Kakaria K, Vazquez J, Basom R, Zhang B, Risler JK, Pollard SM, Nam DH, Delrow JJ, Zhu J, Lee J, Deluca JG, Olson JM, Paddison PJ. (2013). Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells. Cancer Discov. [ link ]
Grover G, DeLuca K, Quirin S, DeLuca JG, Piestun R. (2012). Super-resolution photon-efficient imaging by nano metric double-helix point spread function localization of emitters (SPINDLE). Opt Express. 19:20(24)266681-95. [ link ]
Wiggan O, Shaw AE, DeLuca JG, Bamburg JR. (2012). ADF/cofilin regulates actomyosin assembly through competitive inhibition of myosin II binding to F-actin. Dev Cell. 13:22(3): 530-43. [ link ]
DeLuca JG, Mussacchio A. (2012) Structural organization of the kinetochore-microtubule interface. Cur Opin. Cell Biol. 24(1) 48-56. [ link ]
Varma D, Chandrasekaran S, Sundin LJ, Reidy KT, Wan X, Chasse DA, Nevis KR, DeLuca JG, Salmon ED, Cook JG. (2012). Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Nat Cell Biol. [ link ]
Wiggan O, DeLuca JG. (2011). FORMIN Stable Kinetochore-Microtubule Attachments. Dev Cell 20 (3): 283-4 [ link ]
Sundin LJR, Guimaraes GJ, and DeLuca JG. (2011). The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosis. Molecular Biology of the Cell; 22(6): 759-68 [ link ]
DeLuca KF, Lens SMA, and DeLuca JG. (2011). Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability in mitosis. Journal of Cell Science;124: 622-634 [ link ]
Sundin LJR and DeLuca JG. 2010. Kinetochores: NDC80 toes the line. Current Biology 20: R1083-R1085. [ link ]
Posch M, Khoudoli GA, Swift S, King EM, DeLuca JG, and Swedlow JR. 2010. Sds22 regulates Aurora B activity and microtubule-kinetochore interactions at mitosis. Journal of Cell Biology 191: 61-74. [ link ]
DeLuca JG. (2010) Kinetochore-Microtubule Dynamics and Attachment Stability. Methods Cell Biol. 97C:53-79. [ link ]
DeLuca JG. 2010. Mitosis and the spindle assembly checkpoint. McGraw-Hill Encyclopedia of Science and Technology. 238-240. [ link ]
Pavani SR, DeLuca JG, and Piestun R. (2009) Polarization sensitive, three dimensional, single-molecule imaging of cells with a double-helix system. Opt Express. 17(22):19644-55. [ link ]
Joglekar AP and DeLuca JG. (2009) Chromosome segregation: Ndc80 can carry the load. Curr Biol. 19(10):R404-7. [ link ]
Guimaraes GJ and DeLuca JG. (2009) Connecting with Ska, a key complex at the kinetochore-microtubule interface. EMBO J. 28 (10):1375-7. [ link ]
Wan X, O'Quinn RP, Pierce HL, Joglekar AP, Gall WE, DeLuca JG, Carroll CW, Liu ST, Yen TJ, McEwen BF, Stukenberg PT, Desai A, and Salmon ED. (2009) Protein architecture of the human kinetochore microtubule attachment site. Cell. 137(4):672-84. [link]
Guimaraes GJ, Dong Y, McEwen BF, and Deluca JG. (2008) Kinetochore-microtubule attachment relies on the disordered N-terminal tail domain of Hec1. Curr Biol. 18(22):1778-84. [ link ]
Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A,Polka J, DeLuca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED, and Musacchio A. 2008. Implication for kinetochore-microtuble attachment form the structure of an engineered Ndc80 complex. Cell, 133: 427-39.[ link ]
Bahmanyar S, Kaplan DD, Deluca JG, Giddings TH Jr, O'Toole ET, Winey M, Salmon ED, Casey PJ, Nelson WJ, and Barth AI. (2008) beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev. 22(1):91-105. [ link ]
DeLuca JG. (2007) Spindle microtubules: getting attached at both ends. Curr Biol. 17(22):R966-9. [ link ]
51 DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED. 2006. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell. 127(5):969-82. [ link ]
DeLuca JG, Dong Y, Hergert P, Strauss J, Hickey JM, et al. 2005. Hec1 and Nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. Molecular Biology of the Cell 16: 519-31. [ link ]
Ciferri C, DeLuca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A. 2005. Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. Journal of Biological Chemistry 280:29088-95. [ link ]
Salmon ED, Cimini D, Cameron LA, DeLuca JG. 2005. Merotelic kinetochores in mammalian tissue cells. Philos Trans R Soc Lond B Biol Sci. 360:553-68. [ link ]
DeLuca JG, Salmon ED. 2004. Kinetochores: if you build it, they will come. Current Biology 14: R921-3. [ link ]
Maiato H, DeLuca J, Salmon ED, and Earnshaw WC. 2004. The dynamic kinetochore-microtubule interface. Journal of Cell Science 117: 5461-77. [ link ]
DeLuca JG, Howell BJ, Canman JC, Hickey JM, Fang G, and Salmon ED. 2003. Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores. Current Biology 13: 2103-9. [ link ]
DeLuca JG, Moree B, Hickey JM, Kilmartin JV, and Salmon ED. 2002. hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. Journal of Cell Biology 159: 549-55. [ link ]
Newton CN, DeLuca JG, Himes RH, Miller HP, Jordan MA, and Wilson L. 2002. Intrinsically slow dynamic instability of HeLa cell microtubules in vitro. Journal of Biological Chemistry 277: 42456-62. [ link ]
DeLuca JG, Newton CN, Himes RH, Jordan MA, and Wilson L. 2001. Purification and characterization of native conventional kinesin, HSET, and CENP-E from mitotic HeLa cells. Journal of BiologicalChemistry 276: 28014-21. [ link ]
Waterman-Storer CM, Gregory J, Parsons SF, and Salmon ED. 1995. Membrane/ microtubule tip attachment complexes (TACs) allow the assembly dynamics of plus-ends to push and pull membranes into tubulovesicular networks in interphase Xenopus egg extracts. Journal of Cell Biology 130: 1161-9. [ link ]